16c
1500s, de Medici, Mary I of England, and high-heeled footwear +
1500s, Germany and Christmas trees +
1500s, Great Wall of China, the +
1500s, laboratory mouse; a white mouse +
late 1500s, Italian opera +
1517, Luther and Lutheranism +
1517, Luther and Protestantism +
1525, Rudolff and the square root symbol +
1543, Copernicus and heliocentrism +
1553, Day and the exclamation mark +
1557, Recorde and the equals sign +
c. 1560, Simonio, Bernacotti, and the pencil +
1564, Falloppio and the condom +
1565-1899, Philippines and the bamboo dance +
1578, Frobisher and Thanksgiving Day in North America +
1582, Pope Gregory XIII and the Gregorian calendar +
1587, Sidney and the asterisk symbol +
1587, Sidney and the question mark +
1589, Harington and the flush toilet +
1590, Z. Janssen and the compound microscope +
1592, London and hot cross buns +
1593, Netherlanders and tulips +
1597, Shakespeare, and Romeo and Juliet +
1598, Shakespeare and The Merchant of Venice +